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عمومی::
ابرخانوادهی تسهیل کنندهی اصلی
The five families of MDR efflux pumps are (1) the major facilitator superfamily (MFS), (2) the resistance nodulationdivision (RND) family, (3) the small multidrug resistance (SMR) family, (4) the multidrug and toxic compound extrusion (MATE) family and (5) the adenosine triphosphate (ATP)-binding cassette (ABC) superfamily (Fig. 3).
The MFS, RND, SMR and MATE families are examples of secondary active transporters, more specifically antiporters that transport molecules in opposite directions through the cell membrane.
These include the major facilitator superfamily (MFS), the resistance‐nodulation‐cell division (RND) superfamily, the multidrug and toxic compound extrusion (MATE) superfamily, the small multidrug resistance (SMR) superfamily, and the recently described proteobacterial antimicrobial compound efflux (PACE) family.
8.1.2.1 Bacterial MFS Drug Efflux Pumps
The MFS of solute transporters is currently composed of tens of thousands of members from across all living taxa.
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